Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
- Chemokines
- Cytokine Receptors
- Biomarkers and Buffer Solutions
- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
- Metabolites
- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
- ELISA KIT
- Natural Products
- Lab Equipments
- Humanized Mice for PDX Platform
- Rare Chemicals
- Custom Synthesis
- Antibacterial
- Antifungal
- Antioxidant
- Antiviral
- Molecular Glues
- SARS-CoV
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $65.45 | Total: $327.25 |
| 1 | 10 | $55.44 | Total: $554.40 |
| 1 | 25 | $46.97 | Total: $1,174.25 |
| 1 | 50 | $40.04 | Total: $2,002.00 |
| 1 | 100 | $34.65 | Total: $3,465.00 |
Overview
PD-L1-IN-3 (Compound 4a) functions as an inhibitor of the PD-1PD-L1 axis, with an IC50 value of 4.97 nM for PD-L1 inhibition and an EC50 value of 2.70 ?M for Jurkat T cell modulation. It antagonizes the PD-1PD-L1 interaction by binding to the PD-L1 dimer, obstructing PD-1 signaling. This compound is utilized in research pertaining to lung cancer and melanoma [1].
Chemical Properties
| Molecular Formula | C19H15ClFN2OS |
| Molecular Weight | 373.85 |
| CAS Numbers | 2953044-29-4 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | [Cl].N#CC1=C(OCC2=CC=C(C=C2)CN)SC=C1C=3C=CC(F)=CC3 |
Storage and Handling
0C Short Term, -20C Long Term
References
Wa?y?ska MA, et al. Design, Synthesis, and Biological Evaluation of 2-Hydroxy-4-phenylthiophene-3-carbonitrile as PD-L1 Antagonist and Its Comparison to Available Small Molecular PD-L1 Inhibitors. J Med Chem. 2023 Jul 27;66[14] 9577-9591.