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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $222.70 | Total: $1,113.50 |
| 1 | 10 | $188.64 | Total: $1,886.40 |
| 1 | 25 | $159.82 | Total: $3,995.50 |
| 1 | 50 | $136.24 | Total: $6,812.00 |
| 1 | 100 | $117.90 | Total: $11,790.01 |
Overview
HS 014 acetate is a potent and selective melanocortin MC4 receptor antagonist (Ki values are 3.16, 108, 54.4 and 694 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake in rats and nociception in mice following central administration in vivo. Also inhibits IL-1?-induced Fos expression in the paraventricular hypothalamus.
Chemical Properties
| Molecular Formula | C73H98N20O19S2 |
| Molecular Weight | 1623.83 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CC(N[C@H]1CSSC[C@@H](C(N2CCC[C@H]2C(N3CCC[C@H]3C(N[C@H](C(N[C@H](C(N)=O)CC(O)=O)=O)CCCCN)=O)=O)=O)NC(CNC([C@H](CC4=CNC5=CC=CC=C54)NC([C@H](CCCNC(N)=N)NC([C@@H](CC6=CC7=CC=CC=C7C=C6)NC([C@H](CC8=CNC=N8)NC([C@H](CCC(O)=O)NC1=O)=O)=O)=O)=O)=O)=O)=O.O=C(C)O |
Storage and Handling
0C Short Term, -20C Long Term
References
Bellasio et al [2003] Melanocortin receptor agonists and antagonists modulate nociceptive sensitivity in the mouse formalin test. Eur.J.Pharmacol. 482 127 PMID