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Bretazenil
AOB33721
CAS No:84379-13-5
Chemical Name: (13aS)-8-Bromo-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid 1,1-dimethylethyl ester
993 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $12.75 | Total: $63.75 |
| 1 | 10 | $10.80 | Total: $108.00 |
| 1 | 25 | $9.15 | Total: $228.75 |
| 1 | 50 | $7.80 | Total: $390.00 |
| 1 | 100 | $6.75 | Total: $675.00 |
Overview
Benzodiazepine partial agonist
Chemical Properties
| Molecular Formula | C19H20BrN3O3 |
| Molecular Weight | 418.28 |
| CAS Numbers | 84379-13-5 |
| Solubility | 40 mg in 1 mL DMSO |
| InChl Key | LWUDDYHYYNNIQI-ZDUSSCGKSA-N |
| SMILES Code | O=C(N4[C@]([H])3CCC4)C1=C(Br)C=CC=C1N2C3=C(C(OC(C)(C)C)=O)N=C2 |
| PubChem ID | 107926 |
Storage and Handling
Desiccate at +4°C
Synonyms
Ro 16-6028
References
1) Rundfeldt et al (1995) Anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. Comparison of D.pam, bretazenil and abecarnil. J.Pharmacol.Exp.Ther. 275 693 PMID: 7473156
2) Munro et al (2008) Comparison of the novel subtype-selective GABAA receptor-positive allosteric modulator NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with D.pam, zolpidem, bretazenil, and gaboxadol in rat models of i J.Pharmacol.Exp.Ther. 327 969 PMID: 18791060
3) Puia et al (1992) Molecular mechanisms of the partial allosteric modulatory effects of bretazenil at γ-aminobutyric acid type A receptor. Proc.Natl.Acad.Sci. USA Neurobiology 89 3620
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