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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $35.70 | Total: $178.50 |
| 1 | 10 | $30.24 | Total: $302.40 |
| 1 | 25 | $25.62 | Total: $640.50 |
| 1 | 50 | $21.84 | Total: $1,092.00 |
| 1 | 100 | $18.90 | Total: $1,890.00 |
Overview
Darigabat (PF-06372865) is an orally active and selective GABAA receptor modulator that crosses the blood-brain barrier and exhibits anxiolytic activity, with Ki values of 2.9 nM, 21 nM, and 134 nM for ?2, ?1 PAM, and ?2 PAM, respectively.Darigabat is used in the study of anxiety disorders and epilepsy.
Chemical Properties
| Molecular Formula | C22H21FN4O3S |
| Molecular Weight | 440.49 |
| CAS Numbers | 1614245-70-3 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CCn1cnc2c(cnnc12)-c1ccc(F)c(c1)-c1ccc(cc1OC)S(=O)(=O)CC |
Storage and Handling
0C Short Term, -20C Long Term
References
Owen RM, et al. Design and Identification of a Novel, Functionally Subtype Selective GABAA Positive Allosteric Modulator [PF-06372865]. J Med Chem. 2019 Jun 27;62[12] 5773-5796.