Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
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- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $81.60 | Total: $408.00 |
| 1 | 10 | $69.12 | Total: $691.20 |
| 1 | 25 | $58.56 | Total: $1,464.00 |
| 1 | 50 | $49.92 | Total: $2,496.00 |
| 1 | 100 | $43.20 | Total: $4,320.00 |
Overview
Relacorilant is a selective and orally bioavailable antagonist of glucocorticoid receptor(Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively). Relacorilant has the potential for Cushing
Chemical Properties
| Molecular Formula | C27H22F4N6O3S |
| Molecular Weight | 586.56 |
| CAS Numbers | 1496510-51-0 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C(=O)([C@@]12C(=CC3=C(C1)C=NN3C4=CC=C(F)C=C4)CCN(S(=O)(=O)C5=CN(C)N=C5)C2)C6=CC(C(F)(F)F)=CC=N6 |
Storage and Handling
0C Short Term, -20C Long Term
References
Hunt HJ, et al. Identification of the Clinical Candidate [R]-[1-[4-Fluorophenyl]-6-[[1-methyl-1H-pyrazol-4-yl]sulfonyl]-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl][4-[trifluoromethyl]pyridin-2-yl]methanone [CORT125134] A Selective Glucocorticoid Receptor [GR] Antagonist. J Med Chem. 2017 Apr 27;60[8] 3405-3421.