Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
- Chemokines
- Cytokine Receptors
- Biomarkers and Buffer Solutions
- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
- Metabolites
- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
- ELISA KIT
- Natural Products
- Lab Equipments
- Humanized Mice for PDX Platform
- Rare Chemicals
- Custom Synthesis
- Antibacterial
- Antifungal
- Antioxidant
- Antiviral
- Molecular Glues
- SARS-CoV
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $44.20 | Total: $221.00 |
| 1 | 10 | $37.44 | Total: $374.40 |
| 1 | 25 | $31.72 | Total: $793.00 |
| 1 | 50 | $27.04 | Total: $1,352.00 |
| 1 | 100 | $23.40 | Total: $2,340.00 |
Overview
Mavelertinib (PF-06747775) is an orally available, selective and potent EGFR tyrosine kinase (EGFR TKI) inhibitor with inhibitory effects on T790ML858R and T790MDel, and can be used in the study of oncology and respiratory diseases.
Chemical Properties
| Molecular Formula | C18H22FN9O2 |
| Molecular Weight | 415.42 |
| CAS Numbers | 1776112-90-3 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | COc1nn(C)cc1Nc1nc(nc2n(C)cnc12)N1C[C@@H](F)[C@@H](C1)NC(=O)C=C |
Storage and Handling
0C Short Term, -20C Long Term
References
Planken S, et, al. Discovery of N-[[3R,4R]-4-Fluoro-1-[6-[[3-methoxy-1-methyl-1H-pyrazol-4-yl]amino]-9-methyl-9H-purin-2-yl]pyrrolidine-3-yl]acrylamide [PF-06747775] through Structure-Based Drug Design A High Affinity Irreversible Inhibitor Targeting Onc