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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $208.25 | Total: $1,041.25 |
| 1 | 10 | $176.40 | Total: $1,764.00 |
| 1 | 25 | $149.45 | Total: $3,736.25 |
| 1 | 50 | $127.40 | Total: $6,370.00 |
| 1 | 100 | $110.25 | Total: $11,025.00 |
Overview
BI-4020 is a fourth-generation, orally active, and non-covalent inhibitor of EGFR tyrosine kinase. It exhibits activity against the triple mutant EGFR del19 T790M C797S variant (IC50=0.2 nM in BaF3 cell lines), the double mutant EGFR del19 T790M and primary mutant EGFR del19 (IC50=1 nM), and EGFR wt (IC50=190 nM). BI-4020 also shows high kinome selectivity and good DMPK properties.
Chemical Properties
| Molecular Formula | C30H38N8O2 |
| Molecular Weight | 542.68 |
| CAS Numbers | 2664214-60-0 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C[C@@H]1CCCOc2c(cnn2C)-c2cc(cc(C)n2)C(=O)N=C2Nc3ccc(CN4CCN(C)CC4)cc3N2C1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Engelhardt H,et al. Start selective and rigidify The discovery path towards a next generation of EGFR tyrosine kinase inhibitors. J Med Chem. 2019 Nov 5.