Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
- Chemokines
- Cytokine Receptors
- Biomarkers and Buffer Solutions
- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
- Metabolites
- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
- ELISA KIT
- Natural Products
- Lab Equipments
- Humanized Mice for PDX Platform
- Rare Chemicals
- Custom Synthesis
- Antibacterial
- Antifungal
- Antioxidant
- Antiviral
- Molecular Glues
- SARS-CoV
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $45.90 | Total: $229.50 |
| 1 | 10 | $38.88 | Total: $388.80 |
| 1 | 25 | $32.94 | Total: $823.50 |
| 1 | 50 | $28.08 | Total: $1,404.00 |
| 1 | 100 | $24.30 | Total: $2,430.00 |
Overview
Belzutifan (MK-6482) is a potential treatment for clear cell renal cell carcinoma (ccRCC). Belzutifan is an orally active and selective HIF-2? inhibitor (IC50: 9 nM). Belzutifan , as a second-generation HIF-2? inhibitor, increases potency and improves pharmacokinetic profile.
Chemical Properties
| Molecular Formula | C17H12F3NO4S |
| Molecular Weight | 383.34 |
| CAS Numbers | 1672668-24-4 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CS(=O)(=O)c1ccc(Oc2cc(F)cc(c2)C#N)c2[C@@H](F)[C@@H](F)[C@@H](O)c12 |
Storage and Handling
0C Short Term, -20C Long Term
References
Xu R, et al. 3-[[1S,2S,3R]-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile [PT2977], a Hypoxia-Inducible Factor 2? [HIF-2?] Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma. J Med Chem. 2019 Aug 8;62[15] 6876-6893.