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GNE-9822
AOB33130
CAS: 1557232-32-2
Chemical Name: (S)-N-[1-[3-(Dimethylamino)-1-phenylpropyl]-1H-pyrazol-4-yl]-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxamide
2000 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $58.65 | Total: $293.25 |
| 1 | 10 | $49.68 | Total: $496.80 |
| 1 | 25 | $42.09 | Total: $1,052.25 |
| 1 | 50 | $35.88 | Total: $1,794.00 |
| 1 | 100 | $31.05 | Total: $3,105.00 |
Overview
Potent and selective Interleukin-2 inducible T-cell kinase (ITK) inhibitor
Chemical Properties
| Molecular Formula | C24H32N6O |
| Molecular Weight | 420.56 |
| CAS Numbers | 1557232-32-2 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | (S)-N-[1-[3-(Dimethylamino)-1-phenylpropyl]-1H-pyrazol-4-yl]-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxamide |
| InChl Key | XFYUTGIEFKGWND-NRFANRHFSA-N |
| InChl Code | InChI=1S/C24H32N6O/c1-24(2)12-10-19-20(14-24)27-28-22(19)23(31)26-18-15-25-30(16-18)21(11-13-29(3)4)17-8-6-5-7-9-17/h5-9,15-16,21H,10-14H2,1-4H3,(H,26,31)(H,27,28)/t21-/m0/s1 |
| SMILES Code | O=C(C1=NNC2=C1CCC(C)(C)C2)NC3=CN([C@H](C4=CC=CC=C4)CCN(C)C)N=C3 |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
GNE-9822; GNE 9822; GNE9822.
References
1) Burch JD, Lau K, Barker JJ, Brookfield F, Chen Y, Chen Y, Eigenbrot C, Ellebrandt C, Ismaili MH, Johnson A, Kordt D, MacKinnon CH, McEwan PA, Ortwine DF, Stein DB, Wang X, Winkler D, Yuen PW, Zhang Y, Zarrin AA, Pei Z. Property-and structure-guided discovery of a tetrahydroindazole series of interleukin-2inducible T-cell kinase inhibitors. J Med Chem. 2014 Jul 10;57(13):5714-27. doi:10.1021/jm500550e. Epub 2014 Jun 27. PubMed PMID: 24918870.