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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $27.20 | Total: $136.00 |
| 1 | 10 | $23.04 | Total: $230.40 |
| 1 | 25 | $19.52 | Total: $488.00 |
| 1 | 50 | $16.64 | Total: $832.00 |
| 1 | 100 | $14.40 | Total: $1,440.00 |
Overview
JC2-11 is an inhibitory compound for inflammation.JC2-11 inhibits the recruitment domain-containing proteins NLRC 4, atypical in melanoma 2 (AIM 2) and atypical (NC) inflammatory vesicles by disrupting reactive oxygen species (ROS) production and caspase-1 activity.JC2-11 reduces caspase-1 (p20) secretion, gasdermin D (GSDMD) cleavage, IL-1? and lactate dehydrogenase (LDH) activity in inflammatory vesicles. JC2-11 reduced caspase-1 (p20) secretion, gasdermin D (GSDMD) cleavage, IL-1? and lactate dehydrogenase (LDH) release from inflammatory vesicles.
Chemical Properties
| Molecular Formula | C17H15FO4 |
| Molecular Weight | 302.3 |
| CAS Numbers | 937820-89-8 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C(C=CC1=CC(OC)=C(O)C=C1)(=O)C2=CC(F)=C(OC)C=C2 |
Storage and Handling
0C Short Term, -20C Long Term
References
Lee G, et al. JC2-11, a benzylideneacetophenone derivative, attenuates inflammasome activation. Sci Rep. 2022;12[1] 22484.