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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $34.85 | Total: $174.25 |
| 1 | 10 | $29.52 | Total: $295.20 |
| 1 | 25 | $25.01 | Total: $625.25 |
| 1 | 50 | $21.32 | Total: $1,066.00 |
| 1 | 100 | $18.45 | Total: $1,845.00 |
Overview
VU591 hydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50?0.24 ?M). Thought to block the intracellular pore of the Kir1.1 channel. Exhibits no effect on Kir7.1 at concentrations up to 10 ?M; does not inhibit Kir2.1, Kir2.3 or Kir4.1. Displays similar potency to VU 590
Chemical Properties
| Molecular Formula | C16H13ClN6O5 |
| Molecular Weight | 404.76 |
| CAS Numbers | 1315380-70-1 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Cl.[O-][N+](=O)c1ccc2nc(COCc3nc4ccc(cc4[nH]3)[N+]([O-])=O)[nH]c2c1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Bhave G, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79[1] 42-50.