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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $27.20 | Total: $136.00 |
| 1 | 10 | $23.04 | Total: $230.40 |
| 1 | 25 | $19.52 | Total: $488.00 |
| 1 | 50 | $16.64 | Total: $832.00 |
| 1 | 100 | $14.40 | Total: $1,440.00 |
Overview
CLP257 is a selective K+-Cl? cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 alleviates hypersensitivity in rats with neuropathic painc and it also modulates plasmalemmal KCC2 protein turnover post-translationally. CLP257 restores impaired Cl? transport in neurons with diminished KCC2 activity.
Chemical Properties
| Molecular Formula | C14H14FN3O2S |
| Molecular Weight | 307.34 |
| CAS Numbers | 1181081-71-9 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Oc1cc(F)ccc1C=C1SC(=NC1=O)N1CCCCN1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Gagnon M, et al. Chloride extrusion enhancers as novel therapeutics for neurological diseases. Nat Med. 2013 Nov;19[11] 1524-8.