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CVT-313
AOB1132
CAS: 199986-75-9
Chemical Name: 2-[2-Hydroxyethyl-[6-[(4-methoxyphenyl)methylamino]-9-propan-2-ylpurin-2-yl]amino]ethanol
1000 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $17.85 | Total: $89.25 |
| 1 | 10 | $15.12 | Total: $151.20 |
| 1 | 25 | $12.81 | Total: $320.25 |
| 1 | 50 | $10.92 | Total: $546.00 |
| 1 | 100 | $9.45 | Total: $945.00 |
Overview
Specific inhibitor of CDK2/cyclin A and CDK2/cyclin E
Chemical Properties
| Molecular Formula | C20H28N6O3 |
| Molecular Weight | 400.5 |
| CAS Numbers | 199986-75-9 |
| Solubility | DMSO |
| Purity | 95% by HPLC |
| IUPAC/Chemical Name | 2,2'-[[6-[[(4-methoxyphenyl)methyl]amino]-9-(1-methylethyl)-9H-purin-2-yl]imino]bis-ethanol |
| InChl Key | NQVIIUBWMBHLOZ-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C20H28N6O3/c1-14(2)26-13-22-17-18(21-12-15-4-6-16(29-3)7-5-15)23-20(24-19(17)26)25(8-10-27)9-11-28/h4-7,13-14,27-28H,8-12H2,1-3H3,(H,21,23,24) |
| SMILES Code | OCCN(CCO)C1=NC(N(C(C)C)C=N2)=C2C(NCC3=CC=C(OC)C=C3)=N1 |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
CVT 313; CVT313
References
1) Brooks, E.E., Gray, N.S., Joly, A.H., et al. CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation. J. Biol. Chem. 272(46), 29207-29211 (1997).
2) Bhattacharjee, R.N., Banks, G.C., Trotter, K.W., et al. Histone H1 phosphorylation by Cdk2 selectively modulates mouse mammary tumor virus transcription through chromatin remodeling. Mol. Cell. Biol. 21(16), 5417-5454 (2001).