rac-BDP9066

rac-BDP9066

AOB33803

CAS: 2226507-04-4 (S-Enantiomer)

Chemical Name: 8-(3-(Pyrimidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1,8-diazaspiro[5.5]undecane Dihydrochloride

More details

3997 Items

$31.00

$31.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $26.35 Total: $131.75
110 $22.32 Total: $223.20
125 $18.91 Total: $472.75
150 $16.12 Total: $806.00
1100 $13.95 Total: $1,395.00

Overview

Novel potent and selective MRCK inhibitor, reducing substrate phosphorylation, leading to morphological changes in cancer cells along with inhibition of their motility and invasive character

Chemical Properties

Molecular FormulaC20H26Cl2N6
Molecular Weight421.37
CAS Numbers2226507-04-4 (S-Enantiomer base)
SolubilityDMSO
Purity98% by HPLC
IUPAC/Chemical Name8-(3-(Pyrimidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1,8-diazaspiro[5.5]undecane Dihydrochloride
InChl KeyUELSMLDRSQFVHG-FQEVSTJZSA-N
InChl CodeInChI=1S/C20H24N6/c1-2-8-25-20(6-1)7-3-11-26(13-20)17-5-10-22-19-18(17)15(12-23-19)16-4-9-21-14-24-16/h4-5,9-10,12,14,25H,1-3,6-8,11,13H2,(H,22,23)/t20-/m0/s1
SMILES CodeN(CCC1)(C2=C3C(NC=C3C4=NC=NC=C4)=NC=C2)C[C@@]51CCCCN5

Storage and Handling

0°C (short term), -20°C (long term), desiccated

Synonyms

BDP9066; BDP-9066; BDP 9066

References

1) Unbekandt M, Belshaw S, Bower J, Clarke M, Cordes J, Crighton D, Croft DR, Drysdale MJ, Garnett MJ, Gill K, Gray C, Greenhalgh DA, Hall JAM, Konczal J, Lilla S, McArthur D, McConnell P, McDonald L, McGarry L, McKinnon H, McMenemy C, Mezna M, Morrice NA, Munro J, Naylor G, Rath N, Schüttelkopf AW, Sime M, Olson MF. Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer. Cancer Res. 2018 Apr 15;78(8):2096-2114.

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