Zanubrutinib

Name: Zanubrutinib
Brand: AOBIOUS
SKU: AOB13246
Price: 49 USD
Availability: InStock

Cat No: AOB13246

Condition

CAS: 1691249-45-2

Chemical Name: BGB-3111; (7S)-2-(4-Phenoxyphenyl)-7-(1-prop-2-enoylpiperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

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Quantity Discount Table - Order More To Get More Price Discount

Quantity	mg	Unit Price ($/mg or $/Unit)	Final Price
1	5	$41.65	Total: $208.25
1	10	$35.28	Total: $352.80
1	25	$29.89	Total: $747.25
1	50	$25.48	Total: $1,274.00
1	100	$22.05	Total: $2,205.00

Overview

Novel, Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase (BTK)

Chemical Properties

Molecular Formula	C27H29N5O3
Molecular Weight	471.56
CAS Numbers	1691249-45-2 (S-isomer)
Solubility	DMSO
Purity	98% by HPLC
IUPAC/Chemical Name	(7S)-4,5,6,7-Tetrahydro-7-[1-(1-oxo-2-propen-1-yl)-4-piperidinyl]-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
InChl Key	RNOAOAWBMHREKO-QFIPXVFZSA-N
InChl Code	InChI=1S/C27H29N5O3/c1-2-23(33)31-16-13-18(14-17-31)22-12-15-29-27-24(26(28)34)25(30-32(22)27)19-8-10-21(11-9-19)35-20-6-4-3-5-7-20/h2-11,18,22,29H,1,12-17H2,(H2,28,34)/t22-/m0/s1
SMILES Code	O=C(C1=C2NCC[C@@H](C3CCN(C(C=C)=O)CC3)N2N=C1C4=CC=C(OC5=CC=CC=C5)C=C4)N

Storage and Handling

0°C (short term), -20°C (long term), desiccated

Synonyms

BGB-3111; BGB 3111; BGB3111; Zanubrutinib; Brukinsa.

References

1) Wong J, Cher L, Griffiths J, Cohen A, Huang J, Wang L, Gregory G, Opat S. Efficacy of Zanubrutinib in the Treatment of Bing-Neel Syndrome. Hemasphere. 2018 Nov 30;2(6):e155. doi: 10.1097/HS9.0000000000000155. eCollection 2018 Dec. PubMed PMID: 31723793; PubMed Central PMCID: PMC6745965.

2) Zou YX, Zhu HY, Li XT, Xia Y, Miao KR, Zhao SS, Wu YJ, Wang L, Xu W, Li JY. The impacts of zanubrutinib on immune cells in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma. Hematol Oncol. 2019 Oct;37(4):392-400. doi: 10.1002/hon.2667. Epub 2019 Sep 13. PubMed PMID: 31420873.