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Verosudil (AR-12286)
AOB14409
CAS: 1414854-42-4
Chemical Name: 2-(dimethylamino)-N-(1-oxo- 1,2-dihydroisoquinolin-6-yl)-2-(thiophen-3-yl)acetamide
1000 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $21.25 | Total: $106.25 |
| 1 | 10 | $18.00 | Total: $180.00 |
| 1 | 25 | $15.25 | Total: $381.25 |
| 1 | 50 | $13.00 | Total: $650.00 |
| 1 | 100 | $11.25 | Total: $1,125.00 |
Overview
A potent and selective Rho kinase inhibitor. AR-12286 was well tolerated and provided statistically significant reduction in IOP (intraocular pressure) in patients with XFS (exfoliation syndrome) and OHT (ocular hypertension) or XFG (exfoliative glaucoma). This drug may represent an additional therapeutic paradigm for the treatment of XFG.
Chemical Properties
| Molecular Formula | C17H17N3O2S |
| Molecular Weight | 327.4 |
| CAS Numbers | 1414854-42-4 (free base) |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 2-(dimethylamino)-N-(1-oxo- 1,2-dihydroisoquinolin-6-yl)-2-(thiophen-3-yl)acetamide |
| InChl Key | VDYRZXYYQMMFJW-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C17H17N3O2S/c1-20(2)15(12-6-8-23-10-12)17(22)19-13-3-4-14-11(9-13)5-7-18-16(14)21/h3-10,15H,1-2H3,(H,18,21)(H,19,22) |
| SMILES Code | O=C(NC1=CC2=C(C(NC=C2)=O)C=C1)C(N(C)C)C3=CSC=C3 |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
AR-12286; AR12286; AR 12286; Verosudil; Verosudil free base.
References
1) Skaat A, Jasien JV, Ritch R. Efficacy of Topically Administered Rho-Kinase Inhibitor AR-12286 in Patients With Exfoliation Syndrome and Ocular Hypertension or Glaucoma. J Glaucoma. 2016 Sep;25(9):e807-14. doi: 10.1097/IJG.0000000000000508. PMID: 27552517.
2) Kopczynski C, Novack GD, Swearingen D, van Haarlem T. Ocular hypotensive efficacy, safety and systemic absorption of AR-12286 ophthalmic solution in normal volunteers. Br J Ophthalmol. 2013 May;97(5):567-72. doi: 10.1136/bjophthalmol-2012-302466. Epub 2013 Feb 22. PMID: 23435190.