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PF-06273340
AOB8634
CAS: 1402438-74-7
Chemical Name: N-(5-{[2-Amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl} pyridin-3-yl)-2-(5-chloropyridin-2-yl)acetamide
1000 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $21.25 | Total: $106.25 |
| 1 | 10 | $18.00 | Total: $180.00 |
| 1 | 25 | $15.25 | Total: $381.25 |
| 1 | 50 | $13.00 | Total: $650.00 |
| 1 | 100 | $11.25 | Total: $1,125.00 |
Overview
Highly Potent, Selective and Peripherally Restricted Pan-Trk Inhibitor
Chemical Properties
| Molecular Formula | C23H22ClN7O3 |
| Molecular Weight | 479.93 |
| CAS Numbers | 1402438-74-7 |
| Solubility | DMSO |
| Purity | 99% (HPLC) |
| IUPAC/Chemical Name | N-(5-(2-amino-7-(1-hydroxy-2-methylpropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-3-yl)-2-(5-chloropyridin-2-yl)acetamide |
| InChl Key | BPIWZDNVMQQBQX-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C23H22ClN7O3/c1-23(2,12-32)31-11-18(17-10-28-22(25)30-21(17)31)20(34)13-5-16(9-26-7-13)29-19(33)6-15-4-3-14(24)8-27-15/h3-5,7-11,32H,6,12H2,1-2H3,(H,29,33)(H2,25,28,30) |
| SMILES Code | NC1=NC=C2C(N(C(C)(C)CO)C=C2C(C3=CN=CC(NC(CC4=CC=C(Cl)C=N4)=O)=C3)=O)=N1: |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
PF-06273340; PF 06273340; PF06273340; PF-6273340; PF 6273340; PF6273340.
References
1) Skerratt SE, Andrews MD, Bagal SK, Bilsland J, Brown D, Bungay PJ, Cole S, Gibson KR, Jones R, Morao I, Nedderman A, Omoto K, Robinson C, Ryckmans T, Skinner K, Stupple PA, Waldron G. The Discovery of a Potent, Selective and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain. J Med Chem. 2016 Oct 21. [Epub ahead of print] PubMed PMID: 27766865.