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Poseltinib
AOB14400
CAS: 1353552-97-2
Chemical Name: HM71224; LY3337641; N-[3-[2-[4-(4-Methylpiperazin-1-yl)anilino]furo[3,2-d]pyrimidin-4-yl]oxyphenyl]prop-2-enamide
999 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $14.45 | Total: $72.25 |
| 1 | 10 | $12.24 | Total: $122.40 |
| 1 | 25 | $10.37 | Total: $259.25 |
| 1 | 50 | $8.84 | Total: $442.00 |
| 1 | 100 | $7.65 | Total: $765.00 |
Overview
Novel inhibitor of Bruton's tyrosine kinase (BTK), preventing the activation of the B-cell antigen receptor (BCR) signaling pathway.and the activation of BTK-mediated inflammatory pathways
Chemical Properties
| Molecular Formula | C26H26N6O3 |
| Molecular Weight | 470.53 |
| CAS Numbers | 1353552-97-2 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | N-(3-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)furo[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide |
| InChl Key | LZMJNVRJMFMYQS-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C26H26N6O3/c1-3-23(33)27-19-5-4-6-21(17-19)35-25-24-22(11-16-34-24)29-26(30-25)28-18-7-9-20(10-8-18)32-14-12-31(2)13-15-32/h3-11,16-17H,1,12-15H2,2H3,(H,27,33)(H,28,29,30) |
| SMILES Code | C=CC(NC1=CC=CC(OC2=C(OC=C3)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=N2)=C1)=O |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
Poseltinib; HM 71224; HM-71224; HM71224; LY 3337641; LY3337641; LY-3337641
References
1) Park JK, Byun JY, Park JA, Kim YY, Lee YJ, Oh JI, Jang SY, Kim YH, Song YW, Son J, Suh KH, Lee YM, Lee EB. HM71224, a novel Bruton's tyrosine kinase inhibitor, suppresses B cell and monocyte activation and ameliorates arthritis ina mouse model: a potential drug for rheumatoid arthritis. Arthritis Res Ther. 2016 Apr 18;18:91. doi: 10.1186/s13075-016-0988-z. PubMed PMID: 27090981; PubMed Central PMCID: PMC4835877.
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