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Overview
Etravirine (R165335) is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor. Etravirine is designed to be active against HIV isolates with mutations that confer resistance to the two most commonly prescribed first-generation NNRTIs. It can bind the enzyme reverse transcriptase (RT) in multiple conformations, both for native and mutant RT, thereby blocking the enzymatic activity of RT.
Chemical Properties
| Molecular Formula | C20H15BrN6O |
| Molecular Weight | 435.28 |
| CAS Numbers | 269055-15-4 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | O(C1=NC(NC2=CC=C(C#N)C=C2)=NC(N)=C1Br)C3=C(C)C=C(C#N)C=C3C |
Storage and Handling
0C Short Term, -20C Long Term
References
Das K, et al. J Med Chem, 2004, 47[10], 2550-2560.