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Overview
5-Fluorouracil (5-FU) is a uracil analog and inhibitor of DNA synthesis, exhibiting antitumor activity by affecting pyrimidine synthesis through thymidylate synthase inhibition; it induces apoptosis and autophagy.
Chemical Properties
| Molecular Formula | C4H3FN2O2 |
| Molecular Weight | 130.08 |
| CAS Numbers | 51-21-8 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | FC1=CNC(=O)NC1=O |
Storage and Handling
0C Short Term, -20C Long Term
References
Focaccetti C, et al. Effects of 5-fluorouracil on morphology, cell cycle, proliferation, apoptosis, autophagy and ROS production in endothelial cells and cardiomyocytes. PLoS One.