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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $72.25 | Total: $361.25 |
| 1 | 10 | $61.20 | Total: $612.00 |
| 1 | 25 | $51.85 | Total: $1,296.25 |
| 1 | 50 | $44.20 | Total: $2,210.00 |
| 1 | 100 | $38.25 | Total: $3,825.00 |
Overview
AKI603 is a novel small molecule inhibitor of Aurora kinase A (AurA)(IC50 = 12.3 nM). AKI603 is developed to overcome resistance mediated by BCR-ABL-T315I mutation. AKI603 exhibits strong anti-proliferative activity in leukemic cells[1][2].
Chemical Properties
| Molecular Formula | C19H23N9O2 |
| Molecular Weight | 409.45 |
| CAS Numbers | 1432515-73-5 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(Nc2ccc(cc2)[N+]([O-])=O)n1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Le-Xun Wang, et al. Aurora A Kinase Inhibitor AKI603 Induces Cellular Senescence in Chronic Myeloid Leukemia Cells Harboring T315I Mutation. Sci Rep. 2016 Nov 8;6 35533.