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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $190.40 | Total: $952.00 |
| 1 | 10 | $161.28 | Total: $1,612.80 |
| 1 | 25 | $136.64 | Total: $3,416.00 |
| 1 | 50 | $116.48 | Total: $5,824.00 |
| 1 | 100 | $100.80 | Total: $10,080.00 |
Overview
Alrizomadlin (APG-115) is an orally active MDM2 inhibitor with an IC50 of 3.8 nM and a Ki of 1 nM[1]. It blocks the interaction of MDM2 and p53, inducing cell-cycle arrest and apoptosis in a p53-dependent manner.
Chemical Properties
| Molecular Formula | C34H38Cl2FN3O4 |
| Molecular Weight | 642.59 |
| CAS Numbers | 1818393-16-6 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CCN1[C@H]([C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc3cc(Cl)ccc23)C11CCCCC1)C(=O)NC12CCC(CC1)(CC2)C(O)=O |
Storage and Handling
0C Short Term, -20C Long Term
References
Angelo Aguilar, et al. 4-[[3?R,4?S,5?R]-6?-Chloro-4?-[3-chloro-2-fluorophenyl]-1?-ethyl-2?-oxodispiro[cyclohexane-1,2?-pyrrolidine-3?,3?-indoline]-5?-carboxamido]bicyclo[2.2.2]octane-1-carboxylic Acid [AA-115APG-115] A Potent and Orally Active Murine Double Minute 2 [MDM2] Inhibitor in Clinical Development. J Med Chem. 2017 Apr 13; 60[7] 2819