Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
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- Nuclear Receptor Ligands
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $51.00 | Total: $255.00 |
| 1 | 10 | $43.20 | Total: $432.00 |
| 1 | 25 | $36.60 | Total: $915.00 |
| 1 | 50 | $31.20 | Total: $1,560.00 |
| 1 | 100 | $27.00 | Total: $2,700.00 |
Overview
Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR.
Chemical Properties
| Molecular Formula | C21H18F3N5O |
| Molecular Weight | 413.4 |
| CAS Numbers | 879127-16-9 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | FC(F)(F)c1cccc(Nc2ccnc(Nc3cccc(NC(=O)C4CC4)c3)n2)c1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Zhang Q , Liu Y , Gao F , et al. Discovery of EGFR Selective 4,6-Disubstituted Pyrimidines from a Combinatorial Kinase-Directed Heterocycle Library[J]. Journal of the American Chemical Society, 2006, 128[7] 2182-2183.