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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $34.85 | Total: $174.25 |
| 1 | 10 | $29.52 | Total: $295.20 |
| 1 | 25 | $25.01 | Total: $625.25 |
| 1 | 50 | $21.32 | Total: $1,066.00 |
| 1 | 100 | $18.45 | Total: $1,845.00 |
Overview
GP-82996 (CINK4) is a pharmacological inhibitor specifically targeting CDK46, exhibiting IC50 values of 1.5 ?M for CDK4cyclin D1, 5.6 ?M for CDK6cyclin D1, and 25 ?M for Cdk5p35. It effectively induces apoptosis in U2OS cancer cells, positioning it as a potential investigational tool in cancer research [1] [2].
Chemical Properties
| Molecular Formula | C27H32N6O |
| Molecular Weight | 456.58 |
| CAS Numbers | 359886-84-3 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C(N1C=2C(=CC(NC=3N=C(N[C@@H]4CC[C@@H](O)CC4)C=C(NCC)N3)=CC2)C=C1)C5=CC=CC=C5 |
Storage and Handling
0C Short Term, -20C Long Term
References
Soni R, et al. Selective in vivo and in vitro effects of a small molecule inhibitor of cyclin-dependent kinase 4. J Natl Cancer Inst. 2001 Mar 21;93[6] 436-46.