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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $89.25 | Total: $446.25 |
| 1 | 10 | $75.60 | Total: $756.00 |
| 1 | 25 | $64.05 | Total: $1,601.25 |
| 1 | 50 | $54.60 | Total: $2,730.00 |
| 1 | 100 | $47.25 | Total: $4,725.00 |
Overview
CC-99677 (Gamcemetinib) is a selectively targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune diseases that translates biochemical potency into cellular potency as demonstrated by potent inhibition of heat shock protein 27 (HSP1) phosphorylation in LPS-activated monocyte THP-27 cells via a nucleophilic aromatic substitution (SNAr) mechanism.CC-99677 in Rat experiments demonstrated potency in both biochemical (IC 50 =156.3 nM) and cellular assays (EC 50 =89 nM).
Chemical Properties
| Molecular Formula | C22H20ClN5O3S |
| Molecular Weight | 469.94 |
| CAS Numbers | 1887069-10-4 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CCOCc1cnc(Cl)nc1Oc1ccc2c3c4NC[C@@H](C)NC(=O)c4sc3ccc2n1 |
Storage and Handling
0C Short Term, -20C Long Term
References
RAMIREZ V, et al. METHODS OF TREATING A MK2-MEDIATED DISORDER. WO2020236636.