Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
- Chemokines
- Cytokine Receptors
- Biomarkers and Buffer Solutions
- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
- Metabolites
- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
- ELISA KIT
- Natural Products
- Lab Equipments
- Humanized Mice for PDX Platform
- Rare Chemicals
- Custom Synthesis
- Antibacterial
- Antifungal
- Antioxidant
- Antiviral
- Molecular Glues
- SARS-CoV
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $39.10 | Total: $195.50 |
| 1 | 10 | $33.12 | Total: $331.20 |
| 1 | 25 | $28.06 | Total: $701.50 |
| 1 | 50 | $23.92 | Total: $1,196.00 |
| 1 | 100 | $20.70 | Total: $2,070.00 |
Overview
KU-0060648 is a dual inhibitor of DNA-PK and PI3K?, PI3K?, PI3K? with IC50 values of 8.6 nM, 4 nM, 0.5 nM, and 0.1 nM respectively, and demonstrates less inhibition of PI3K? with an IC50 of 0.59 ?M.
Chemical Properties
| Molecular Formula | C33H34N4O4S |
| Molecular Weight | 582.71 |
| CAS Numbers | 881375-00-4 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CCN1CCN(CC(=O)Nc2ccc(-c3cccc4c3oc(cc4=O)N3CCOCC3)c3sc4ccccc4c23)CC1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Munck JM, et al. Mol Cancer Ther, 2012, 11[8], 1789-1798.