Categories
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $91.80 | Total: $459.00 |
| 1 | 10 | $77.76 | Total: $777.60 |
| 1 | 25 | $65.88 | Total: $1,647.00 |
| 1 | 50 | $56.16 | Total: $2,808.00 |
| 1 | 100 | $48.60 | Total: $4,860.00 |
Overview
MSC 2032964A is a potent selective ASK1 inhibitor (IC50 = 93 nM) that is oral bioavailable and brain permeable. It inhibited neuroinflammation in mouse EAE models and blocked LPS-induced phosphorylation of ASK1 and p38 in cultured mouse astrocytes.
Chemical Properties
| Molecular Formula | C16H13F3N6O |
| Molecular Weight | 362.31 |
| CAS Numbers | 1124381-43-6 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | FC(F)(F)c1cc(NC2CC2)n2nc(NC(=O)c3cccnc3)nc2c1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Kawarazaki Y, Ichijo H, Naguro I. Apoptosis signal-regulating kinase 1 as a therapeutic target. Expert Opin Ther Targets. 2014 Jun;18[6] 651-64.