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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $23.80 | Total: $119.00 |
| 1 | 10 | $20.16 | Total: $201.60 |
| 1 | 25 | $17.08 | Total: $427.00 |
| 1 | 50 | $14.56 | Total: $728.00 |
| 1 | 100 | $12.60 | Total: $1,260.00 |
Overview
CCT245737 (SRA737) is an orally active and selective Chk1 inhibitor (IC50: 1.3 nM); CCT245737 shows much less activity against Chk2 (IC50: 2440 nM).
Chemical Properties
| Molecular Formula | C16H16F3N7O |
| Molecular Weight | 379.34 |
| CAS Numbers | 1489389-18-5 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | FC(F)(F)c1cnc(Nc2cnc(cn2)C#N)cc1NC[C@H]1CNCCO1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Osborne JD, et al. Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 [CHK1] Inhibitor Clinical Candidate [R]-5-[[4-[[Morpholin-2-ylmethyl]amino]-5-[trifluoromethyl]pyridin-2-yl]amino]pyrazine-2-carbonitrile [CCT245737]. J Med Chem. 2016 Jun 9;59[11] 5221-37.