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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $46.75 | Total: $233.75 |
| 1 | 10 | $39.60 | Total: $396.00 |
| 1 | 25 | $33.55 | Total: $838.75 |
| 1 | 50 | $28.60 | Total: $1,430.00 |
| 1 | 100 | $24.75 | Total: $2,475.00 |
Overview
Taletrectinib free base (AB-106 free base) is a novel potent, selective and orally active ROS1NTRK inhibitor.Taletrectinib free base has potent inhibitory effects on recombinant ROS1, NTRK1, NTRK2, and NTRK3, with IC50s of 0.207, 0.622, 2.28 and 0.98 nM, respectively, Taletrectinib free base also inhibited ROS1 G2032R and other Crizotinib-resistant ROS1 mutations.
Chemical Properties
| Molecular Formula | C23H24FN5O |
| Molecular Weight | 405.47 |
| CAS Numbers | 1505514-27-1 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | N([C@H](C)C1=CC(F)=CC=C1)C2=NN3C(=CN=C3C=C2)C4=CC=C(OC[C@@H](C)N)C=C4 |
Storage and Handling
0C Short Term, -20C Long Term
References
Katayama R, et al. The new-generation selective ROS1NTRK inhibitor DS-6051b overcomes crizotinib resistant ROS1-G2032R mutation in preclinical models. Nat Commun. 2019;10[1] 3604.