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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $32.30 | Total: $161.50 |
| 1 | 10 | $27.36 | Total: $273.60 |
| 1 | 25 | $23.18 | Total: $579.50 |
| 1 | 50 | $19.76 | Total: $988.00 |
| 1 | 100 | $17.10 | Total: $1,710.00 |
Overview
Repotrectinib (TPX-0005) is a potent ALKROS1TRK inhibitor, with IC50 values of 1.01 nM for WT ALK, 5.3 nM for SRC, 1.08 nM for ALK L1196M, and 1.26 nM for ALK G1202R.
Chemical Properties
| Molecular Formula | C18H18FN5O2 |
| Molecular Weight | 355.37 |
| CAS Numbers | 1802220-02-5 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C[C@H]1CNC(=O)c2cnn3ccc(N[C@H](C)c4cc(F)ccc4O1)nc23 |
Storage and Handling
0C Short Term, -20C Long Term
References
Dayong Zhai, et al. Abstract 2132 The novel, rationally-designed, ALKSRC inhibitor TPX-0005 overcomes multiple acquired resistance mechanisms to current ALK inhibitors. Cancer Research. July 2016