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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $108.80 | Total: $544.00 |
| 1 | 10 | $92.16 | Total: $921.60 |
| 1 | 25 | $78.08 | Total: $1,952.00 |
| 1 | 50 | $66.56 | Total: $3,328.00 |
| 1 | 100 | $57.60 | Total: $5,760.00 |
Overview
BRD0705 is a potent, orally active GSK3? inhibitor with high selectivity (IC50: 66 nM; Kd: 4.8 ?M), demonstrating an 8-fold higher selectivity for GSK3? compared to GSK3? (IC50: 515 nM).
Chemical Properties
| Molecular Formula | C20H23N3O |
| Molecular Weight | 321.42 |
| CAS Numbers | 2056261-41-5 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CC[C@@]1(C2=CNNC2=NC2=C1C(=O)CC(C)(C)C2)c1ccccc1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Wagner FF, et al. Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med. 2018 Mar 7;10[431]. pii eaam8460.