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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $91.80 | Total: $459.00 |
| 1 | 10 | $77.76 | Total: $777.60 |
| 1 | 25 | $65.88 | Total: $1,647.00 |
| 1 | 50 | $56.16 | Total: $2,808.00 |
| 1 | 100 | $48.60 | Total: $4,860.00 |
Overview
GNF4877 is a potent inhibitor of DYRK1A and GSK3? (IC50s: 6 nM and 16 nM, respectively), resulting in the blockade of nuclear export of nuclear factor of activated T-cells (NFATc) and increased ?-cell proliferation.
Chemical Properties
| Molecular Formula | C25H27FN6O4 |
| Molecular Weight | 494.52 |
| CAS Numbers | 2041073-22-5 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CC(C)Oc1ccc(F)c(c1)-c1cnc(N)c(n1)C(=O)Nc1cnccc1N1CCC[C@H](C1)C(O)=O |
Storage and Handling
0C Short Term, -20C Long Term
References
Shen W, et al. Inhibition of DYRK1A and GSK3? induces human ?-cell proliferation. Nat Commun. 2015 Oct 26;6 8372.