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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $990.25 | Total: $4,951.25 |
| 1 | 10 | $838.80 | Total: $8,388.00 |
| 1 | 25 | $710.65 | Total: $17,766.26 |
| 1 | 50 | $605.80 | Total: $30,290.00 |
| 1 | 100 | $524.25 | Total: $52,425.02 |
Overview
MIV-247 is a selective and potent inhibitor of cathepsin S (Kis 2.1, 4.2, and 7.5 nM for human, mouse, and wild monkey cathepsin S, respectively), which attenuates mechanical anomalies in preclinical models of neuropathic pain, and can be used to study cardiac muscle injury.
Chemical Properties
| Molecular Formula | C17H24F3N3O4 |
| Molecular Weight | 391.39 |
| CAS Numbers | 1352817-76-5 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | N(C([C@H](CC1(F)CCCC1)NC(C(C)(F)F)=O)=O)C2(C(C(N)=O)=O)CCC2 |
Storage and Handling
0C Short Term, -20C Long Term
References
Hewitt E. et al. Selective Cathepsin S Inhibition with MIV-247 Attenuates Mechanical Allodynia and Enhances the Antiallodynic Effects of Gabapentin and Pregabalin in a Mouse Model of Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358[3] 387-96.