Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
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- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
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- Cancer Research
- Epigenetics
- Metabolites
- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
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- Antifungal
- Antioxidant
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- Molecular Glues
- SARS-CoV
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $354.45 | Total: $1,772.25 |
| 1 | 10 | $300.24 | Total: $3,002.40 |
| 1 | 25 | $254.37 | Total: $6,359.25 |
| 1 | 50 | $216.84 | Total: $10,842.00 |
| 1 | 100 | $187.65 | Total: $18,765.01 |
Overview
MK-0674 is an orally available, selective and potent cathepsin K inhibitor (IC50: 0.4 nM) that inhibits Cat B, Cat F, Cat L, and Cat S. It can be used in metabolism-related diseases.
Chemical Properties
| Molecular Formula | C26H27F6N3O2 |
| Molecular Weight | 527.5 |
| CAS Numbers | 887781-62-6 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | N(C([C@@H](N[C@H]([C@](F)(F)F)C1=CC=C(C=C1)C2=CC=C([C@H](C(F)F)O)C=C2)CC(C)(C)F)=O)C3(C#N)CC3 |
Storage and Handling
0C Short Term, -20C Long Term
References
Isabel E, et al. The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor. Bioorg Med Chem Lett. 2010 Feb 1;20[3] 887-92.