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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $29.75 | Total: $148.75 |
| 1 | 10 | $25.20 | Total: $252.00 |
| 1 | 25 | $21.35 | Total: $533.75 |
| 1 | 50 | $18.20 | Total: $910.00 |
| 1 | 100 | $15.75 | Total: $1,575.00 |
Overview
NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 ?M). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively). It also enhances the apoptotic effect and has anti-cancer activity.
Chemical Properties
| Molecular Formula | C23H30N6O2 |
| Molecular Weight | 422.52 |
| CAS Numbers | 444723-13-1 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CCN(CC)C(=O)c1ccc(Nc2nc(OCC3CCCCC3)c3[nH]cnc3n2)cc1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Pennati M, et al. Potentiation of apoptosis by the novel cyclin-dependent kinase inhibitor NU6140 a possible role for survivin down-regulation. Mol Cancer Ther. 2005 Sep;4[9] 1328-37.