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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $52.70 | Total: $263.50 |
| 1 | 10 | $44.64 | Total: $446.40 |
| 1 | 25 | $37.82 | Total: $945.50 |
| 1 | 50 | $32.24 | Total: $1,612.00 |
| 1 | 100 | $27.90 | Total: $2,790.00 |
Overview
CA 074 is a potent inhibitor of cathepsin B with a Ki value of 2 to 5 nM.CA 074 inhibits ischemic hippocampal neuronal death in primates and attenuates retinopathy and optic neuritis in experimental autoimmune encephalomyelitis induced by SJLJ mice.
Chemical Properties
| Molecular Formula | C18H29N3O6 |
| Molecular Weight | 383.44 |
| CAS Numbers | 134448-10-5 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | [H][C@](NC(=O)[C@H]1O[C@@H]1C(=O)NCCC)([C@@H](C)CC)C(=O)N1CCC[C@H]1C(O)=O |
Storage and Handling
0C Short Term, -20C Long Term
References
Yamashima T, et al. Inhibition of ischaemic hippocampal neuronal death in primates with cathepsin B inhibitor CA-074 a novel strategy for neuroprotection based on 'calpain-cathepsin hypothesis'. Eur J Neurosci. 1998 May;10[5] 1723-33.