Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
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- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $22.10 | Total: $110.50 |
| 1 | 10 | $18.72 | Total: $187.20 |
| 1 | 25 | $15.86 | Total: $396.50 |
| 1 | 50 | $13.52 | Total: $676.00 |
| 1 | 100 | $11.70 | Total: $1,170.00 |
Overview
NSC 66811is a novel inhibitor of the murine double minute 2 (MDM2)-p53 interaction. It binds to MDM2 with a Ki of 120 nM and activates p53 in cancer cells with a mechanism of action consistent with targeting the MDM2-p53 interaction.
Chemical Properties
| Molecular Formula | C23H20N2O |
| Molecular Weight | 340.42 |
| CAS Numbers | 6964-62-1 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Cc1ccc2ccc(C(Nc3ccccc3)c3ccccc3)c(O)c2n1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Yipin Lu, et al. Discovery of a nanomolar inhibitor of the human murine double minute 2 [MDM2]-p53 interaction through an integrated, virtual database screening strategy. J Med Chem. 2006 Jun 29;49[13] 3759-62.