Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
- Chemokines
- Cytokine Receptors
- Biomarkers and Buffer Solutions
- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
- Metabolites
- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
- ELISA KIT
- Natural Products
- Lab Equipments
- Humanized Mice for PDX Platform
- Rare Chemicals
- Custom Synthesis
- Antibacterial
- Antifungal
- Antioxidant
- Antiviral
- Molecular Glues
- SARS-CoV
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $42.50 | Total: $212.50 |
| 1 | 10 | $36.00 | Total: $360.00 |
| 1 | 25 | $30.50 | Total: $762.50 |
| 1 | 50 | $26.00 | Total: $1,300.00 |
| 1 | 100 | $22.50 | Total: $2,250.00 |
Overview
PERK-IN-4 is a potent and selective PERK inhibitor with an IC50 value of 0.3 nM, used in the study of cancer and neurological disorders.
Chemical Properties
| Molecular Formula | C24H19F4N5O |
| Molecular Weight | 469.43 |
| CAS Numbers | 1337531-89-1 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Cn1cc(-c2ccc3N(CCc3c2)C(=O)Cc2cc(F)cc(c2)C(F)(F)F)c2c(N)ncnc12 |
Storage and Handling
0C Short Term, -20C Long Term
References
Axten JM, et al. Discovery of 7-methyl-5-[1-{[3-[trifluoromethyl]phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine [GSK2606414], a potent and selective first-in-class inhibitor of protein kinase R [PKR]-like endoplasmic reticulum kinase [PERK]. J Med Chem. 2012;55[16] 7193-7207.