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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $106.25 | Total: $531.25 |
| 1 | 10 | $90.00 | Total: $900.00 |
| 1 | 25 | $76.25 | Total: $1,906.25 |
| 1 | 50 | $65.00 | Total: $3,250.00 |
| 1 | 100 | $56.25 | Total: $5,625.00 |
Overview
(1S,2R)-Alicapistat ((1S,2R)-ABT-957) is a highly efficient, orally active compound that selectively inhibits human calpains 1 and 2, showing promise for Alzheimer's disease (AD) therapy [1]. It effectively addresses the metabolic liability associated with carbonyl reduction and demonstrates potent inhibition of calpain 1 with an IC50 value of 395 nM [2].
Chemical Properties
| Molecular Formula | C25H27N3O4 |
| Molecular Weight | 433.5 |
| CAS Numbers | 2221010-57-5 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | O=C(N[C@@H](Cc1ccccc1)C(=O)C(=O)NC1CC1)[C@H]1CCC(=O)N1Cc1ccccc1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Lon HK, et al. Pharmacokinetics, Safety, Tolerability, and Pharmacodynamics of Alicapistat, a Selective Inhibitor of Human Calpains 1 and 2 for the Treatment of Alzheimer Disease An Overview of Phase 1 Studies. Clin Pharmacol Drug Dev. 2019 Apr. 8[3] 290.