Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $84.15 | Total: $420.75 |
| 1 | 10 | $71.28 | Total: $712.80 |
| 1 | 25 | $60.39 | Total: $1,509.75 |
| 1 | 50 | $51.48 | Total: $2,574.00 |
| 1 | 100 | $44.55 | Total: $4,455.00 |
Overview
HOIPIN-8 is a potent inhibitor of the linear ubiquitin chain assembly complex (LUBAC) with an IC50 of 11 nM. As a derivative of HOIPIN-1, it exhibits 255-fold greater inhibition of both petit-LUBAC and TNF-?-mediated NF-?B activation compared to HOIPIN-1. HOIPIN-8 is a promising tool to explore cellular functions of LUBAC.
Chemical Properties
| Molecular Formula | C23H15F2N4NaO3 |
| Molecular Weight | 456.38 |
| CAS Numbers | 2519537-70-1 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | O=C(C1=CC=C(C2=CN(C)N=C2)C=C1C=CC(C3=C(C=C(C4=CNN=C4)C=C3F)F)=O)[O-].[Na+] |
Storage and Handling
0C Short Term, -20C Long Term