Categories
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- Protein Control Ligand
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $49.30 | Total: $246.50 |
| 1 | 10 | $41.76 | Total: $417.60 |
| 1 | 25 | $35.38 | Total: $884.50 |
| 1 | 50 | $30.16 | Total: $1,508.00 |
| 1 | 100 | $26.10 | Total: $2,610.00 |
Overview
EB1 is a potent and selective MNK kinase inhibitor with inhibitory effects on MNK1 and MNK2 with IC50 values of 0.69 ?M and 9.4 ?M, respectively.EB1 inhibits the growth of cancer cells, promotes apoptosis, and inhibits the phosphorylation of eIF4E.
Chemical Properties
| Molecular Formula | C18H14N4 |
| Molecular Weight | 286.33 |
| CAS Numbers | 42951-68-8 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | NC=1C2=C(C=C(N=C2NN1)C3=CC=CC=C3)C4=CC=CC=C4 |
Storage and Handling
0C Short Term, -20C Long Term
References
Aboukhatwa SM, et al. Nicotinonitrile-derived apoptotic inducers Design, synthesis, X-ray crystal structure and Pim kinase inhibition. Bioorg Chem. 2022 Dec;129 106126.