Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
- Chemokines
- Cytokine Receptors
- Biomarkers and Buffer Solutions
- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
- Metabolites
- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
- ELISA KIT
- Natural Products
- Lab Equipments
- Humanized Mice for PDX Platform
- Rare Chemicals
- Custom Synthesis
- Antibacterial
- Antifungal
- Antioxidant
- Antiviral
- Molecular Glues
- SARS-CoV
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $365.50 | Total: $1,827.50 |
| 1 | 10 | $309.60 | Total: $3,096.00 |
| 1 | 25 | $262.30 | Total: $6,557.50 |
| 1 | 50 | $223.60 | Total: $11,180.00 |
| 1 | 100 | $193.50 | Total: $19,350.01 |
Overview
AUTAC1 is a MetAP2-targeted autophagy-mediated degrader (AUTAC) with potential anticancer activity that degrades MetAP2 and FKBP12 proteins and can be used to synthesize PROTAC.
Chemical Properties
| Molecular Formula | C44H63FN8O11S |
| Molecular Weight | 931.08 |
| CAS Numbers | 2241669-09-8 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C[C@@]1([C@@]2([C@@]3(CO3)CC[C@@H](OC(NCCCOCCOCCOCCCNC([C@H](CSC=4N(CC5=CC=C(F)C=C5)C6=C(N4)C(=O)N=C(N)N6)NC(C)=O)=O)=O)[C@H]2OC)[H])[C@H](CC=C(C)C)O1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Daiki Takahashi, et al. AUTACs Cargo-Specific Degraders Using Selective Autophagy. Mol Cell. 2019 Dec 5;76[5] 797-810.e10.