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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $118.15 | Total: $590.75 |
| 1 | 10 | $100.08 | Total: $1,000.80 |
| 1 | 25 | $84.79 | Total: $2,119.75 |
| 1 | 50 | $72.28 | Total: $3,614.00 |
| 1 | 100 | $62.55 | Total: $6,255.00 |
Overview
hSMG-1 inhibitor 11j is a pyrimidine derivative. hSMG-1 inhibitor 11j is a potent and selective inhibitor of hSMG-1, IC50 = 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3K?? (IC50=9260 nM) and CDK1CDK2 (IC50=327.1 ?M). hSMG-1 inhibitor 11j can be used for the research of cancer.
Chemical Properties
| Molecular Formula | C27H28ClN7O3S |
| Molecular Weight | 566.07 |
| CAS Numbers | 1402452-15-6 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CCN(CC)S(=O)(=O)c1cc(Nc2nccc(n2)-c2ccnc(c2)-c2ccc(NC(=O)NC)cc2)ccc1Cl |
Storage and Handling
0C Short Term, -20C Long Term
References
Gopalsamy A, et, al. Identification of pyrimidine derivatives as hSMG-1 inhibitors. Bioorg Med Chem Lett. 2012 Nov 1;22[21] 6636-41.