Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
- Chemokines
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- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
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- Customized Screening Library
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- Primary Cells
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $66.30 | Total: $331.50 |
| 1 | 10 | $56.16 | Total: $561.60 |
| 1 | 25 | $47.58 | Total: $1,189.50 |
| 1 | 50 | $40.56 | Total: $2,028.00 |
| 1 | 100 | $35.10 | Total: $3,510.00 |
Overview
ASK1-IN-1 is an inhibitor of apoptosis signal-regulating kinase 1 which is a key mediator in the apoptotic and inflammatory cellular stress response with an IC50 of 21 nM in biochemica assays.
Chemical Properties
| Molecular Formula | C19H19N9O2 |
| Molecular Weight | 405.41 |
| CAS Numbers | 2411382-24-4 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | COc1nn(cc1C(=O)Nc1cccc(n1)-c1nncn1C(C)C)-c1cnccn1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Xin Z, et al. Discovery of CNS-Penetrant Apoptosis Signal-Regulating Kinase 1 [ASK1] Inhibitors. ACS Med Chem Lett. 2020;11[4] 485-490. Published 2020 Feb 12.