Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $47.60 | Total: $238.00 |
| 1 | 10 | $40.32 | Total: $403.20 |
| 1 | 25 | $34.16 | Total: $854.00 |
| 1 | 50 | $29.12 | Total: $1,456.00 |
| 1 | 100 | $25.20 | Total: $2,520.00 |
Overview
GNE-495 is a potent and specific inhibitor of MAP4K4 with an IC50 of 3.7 nM.
Chemical Properties
| Molecular Formula | C22H20FN5O2 |
| Molecular Weight | 405.42 |
| CAS Numbers | 1449277-10-4 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Nc1ncc(C(=O)NC2CN(C2)C(=O)C2CC2)c2ccc(nc12)-c1cccc(F)c1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Ndubaku CO et al. Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis. ACS Med Chem Lett. 2015 Jun 29;6[8] 913-8.