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Overview
Aminoadipic acid (DL-2-Aminoadipic acid) (2-aminoadipate) is a metabolite in the principal biochemical pathway of lysine. It is an intermediate in the metabolism (i.e. breakdown or degradation) of lysine and saccharopine. It antagonizes neuroexcitatory activity modulated by the glutamate receptor N-methyl-D-aspartate (NMDA). Aminoadipic acid has also been shown to inhibit the production of kynurenic acid, a broad spectrum excitatory amino acid receptor antagonist, in brain tissue slices.
Chemical Properties
| Molecular Formula | C6H11NO4 |
| Molecular Weight | 161.16 |
| CAS Numbers | 542-32-5 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | |
| InChl Key | |
| InChl Code | |
| SMILES Code | C(C(C(O)=O)N)CCC(O)=O |
Storage and Handling
0C Short Term, -20C Long Term
Synonyms
References
Wang TJ, et al. 2-Aminoadipic acid is a biomarker for diabetes risk. J Clin Invest. 2013 Oct;123[10] 4309-17.