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Overview
3-Methyladipic acid is a metabolite of the catabolism of phytanic acid. Patients with adult Refsums disease (ARD) are unable to detoxify phytanic acid by alpha-oxidation, and so the w-oxidation pathway is the only metabolic pathway available for phytanic acid degradation. This pathway produces 3-methyladipic acid as the final metabolite, which is excreted in the urine.
Chemical Properties
| Molecular Formula | C7H12O4 |
| Molecular Weight | 160.17 |
| CAS Numbers | 3058-01-3 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CC(CCC(O)=O)CC(O)=O |
Storage and Handling
0C Short Term, -20C Long Term
References
Wierzbicki AS, et al. Refsum's disease a peroxisomal disorder affecting phytanic acid alpha-oxidation. J Neurochem. 2002 Mar;80[5] 727-35.