ML381 (VU0488130) Fumarate

Name: ML381 (VU0488130) Fumarate
Brand: AOBIOUS
SKU: AOB2555
Price: 67 USD
Availability: InStock

Cat No: AOB2555

Condition

CAS No: 1623481-80-0 (free base)

Chemical Name: VU0488130; 5-[(3-Acetylphenoxy)methyl]-N-methyl-N-[(1S)-1-pyridin-2-ylethyl]-1,2-oxazole-3-carboxamide fumarate

AOBIOUS launched this product in 2017

CITATIONS - Publications That Use AOBIOUS Product

1) Am J Physiol Gastrointest Liver Physiol 315: G473–G483 (2018)

More details

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Quantity Discount Table - Order More To Get More Price Discount

Quantity	mg	Unit Price ($/mg or $/Unit)	Final Price
1	5	$56.95	Total: $284.75
1	10	$48.24	Total: $482.40
1	25	$40.87	Total: $1,021.75
1	50	$34.84	Total: $1,742.00
1	100	$30.15	Total: $3,015.00

Overview

Highly Muscarinic Acetylcholine Receptor (mAChR)-Selective M5-Orthosteric Antagonist

Chemical Properties

Molecular Formula	C25H25N3O8
Molecular Weight	495.48
CAS Numbers	1623481-80-0 (Free Base)
Solubility	DMSO
Purity	98% by HPLC
IUPAC/Chemical Name	5-[(3-acetylphenoxy)methyl]-N-methyl-N-[(1S)-1-pyridin-2-ylethyl]-1,2-oxazole-3-carboxamide
InChl Key	JMYDHMCYZKRDPD-AWEZNQCLSA-N
InChl Code	InChI=1S/C21H21N3O4/c1-14(19-9-4-5-10-22-19)24(3)21(26)20-12-18(28-23-20)13-27-17-8-6-7-16(11-17)15(2)25/h4-12,14H,13H2,1-3H3/t14-/m0/s1
SMILES Code	O=C(C1=NOC(COC2=CC=CC(C(C)=O)=C2)=C1)N(C)[C@H](C3=NC=CC=C3)C

Storage and Handling

0°C (short term), -20°C (long term), desiccated

Synonyms

ML381; ML 381; ML-381; VU0488130; VU-0488130; VU 0488130.

References

1) Gentry PR, etc. Development of a Novel, Orthosteric M5 Antagonist Possessing a High Degree of Muscarinic Subtype Selectivity. 2013 Dec 15 [updated 2015 Feb 11]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available from http://www.ncbi.nlm.nih.gov/books/NBK280056/ PubMed PMID: 25834910.

2) Gentry PR, Kokubo M, Bridges TM, Cho HP, Smith E, Chase P, Hodder PS, Utley TJ, Rajapakse A, Byers F, Niswender CM, Morrison RD, Daniels JS, Wood MR, Conn PJ, Lindsley CW. Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probe. ChemMedChem. 2014 Aug;9(8):1677-82.