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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $109.65 | Total: $548.25 |
| 1 | 10 | $92.88 | Total: $928.80 |
| 1 | 25 | $78.69 | Total: $1,967.25 |
| 1 | 50 | $67.08 | Total: $3,354.00 |
| 1 | 100 | $58.05 | Total: $5,805.00 |
Overview
SIM-688 is a selective and orally active estrogen receptor inhibitor of NF-?B transcriptional activity (IC50 = 122 nM in HAECT-1 cells).
Chemical Properties
| Molecular Formula | C34H31F3N2O2 |
| Molecular Weight | 556.62 |
| CAS Numbers | 796854-35-8 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | COc1ccccc1[C@H](c1cccc2ccccc12)[C@@](C)(C#N)C(=O)N1CCC(CC1)c1cccc(c1)C(F)(F)F |
Storage and Handling
0C Short Term, -20C Long Term
References
Caggiano TJ, et al. Estrogen receptor dependent inhibitors of NF-kappaB transcriptional activation-1 synthesis and biological evaluation of substituted 2-cyanopropanoic acid derivatives pathway selective inhibitors of NF-kappaB, a potential treatment for rheumatoid arthritis. J Med Chem. 2007 Nov 1;50[22] 5245-8.