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Overview
Busulfan (Busulphan) is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription.
Chemical Properties
| Molecular Formula | C6H14O6S2 |
| Molecular Weight | 246.3 |
| CAS Numbers | 55-98-1 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | |
| InChl Key | |
| InChl Code | |
| SMILES Code | CS(=O)(=O)OCCCCOS(C)(=O)=O |
Storage and Handling
0C Short Term, -20C Long Term
Synonyms
References
Meng A, et al. Cancer Res, 2003, 63[17], 5414-5419.